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Technologies

Infectious Disease Models


Bacterial and DFAP Signals From The Brain of a Mouse with Pneumococcal Meningitis



In vivo images of brains from mice with meningitis at 19h postinfection. Much of the bacterial signal comes from discrete patches, whereas GFAP is induced in the entire brain and there are different intensities of the bioluminescence signal in certain regions of the brain.

Publication: Infection And Immunity, Dec. 2005, p. 7836-7843 Vol. 73, No. 12






Bioluminescent Bacterial Biofilms


Monitoring the level of bioluminescence activity of P. aeruginosa and S. aureus of a 2-day-old biofilm on catheter segment. Note the lack of light signal from catheter colonized with parental strains or control catheters, indicating the specificity of the detection system.

Publication: Infection And Immunity, Feb. 2003, p. 882-890 Vol. 71, No. 2
















Biofilm Infection in Mouse Model


In vitro monitoring of the level of bioluminescence activity of P. aeruginosa and S. aureus of a 2-day-old biofilm on catheter segment. Note the lack of light signal from catheter colonized with parental strains or control catheters, indicating the specificity of the detection system.
















Identification of Proteus mirabilis Non-swarming Mutant


The strain was spotted in the center of a LB-agar plate, and incubated at 37°C for 16 hours. The swarming Xen 44 displayed periodic repeating cycles of swarming and consolidation phases, characteristic to wild type P. mirabilis. The bioluminescent Xen 45 appeared to be defective in the swarming ability.