γGcs-h-luc
Overview
γGcs-h-luc BP (P/N 119338) Breeding Pair or γGcs-h-luc (P/N 119353) Individual Animal
Light producing animal model (LPTA®) Crl:CD-1 (ICR)BR-Tg(γGcs-h-luc)Xen, commonly called γGcs-h-luc, carries a transgene containing a 14 kb segment of the mouse y-glutamylcysteine synthetase catalytic (heavy) subunit (γGcs-h) promoter, an 850 bp human ß-globin intron 2, and modified firefly luciferase cDNA (Promega pGL-3). Basal expression of the reporter was high in liver and thyroid gland, with liver signals in males nearly twice as high as females. CdCl2 and chloroform induced luciferase expression in liver in a time-dependent manner. This LPTA® animal model is available from Xenogen Biosciences, Cranbury, New Jersey, USA.
| Model: | Drug Metabolism/Toxicity Model |
| Mouse Strain: | Crl:CD-1 (ICR)BR-Tg(yGcs-h-luc)-Xen |
| Common Name: | γGcs-h-luc |
| Genotype: | Hemizygote |
| Background Strain: | Crl:CD-1 (ICR)BRB |
| Coat Color: | Albino |
Applications
The γGcs-h-luc LPTA® animal model is useful in studying indications of possible heavy metal and chemical toxicity such as CdCl2, chloroform, and MeHg. The model may also be used to study chemopreventive agents.
