CYP3a11-luc

Overview

CYP3a11-luc BP (P/N 119279) Breeding Pair or CYP3a11-luc (P/N 119301) Individual Animal

Light producing animal model (LPTA®) FVB/N-Tg(Cyp3a11-luc)-Xen, commonly called Cyp3a11-luc, carries a transgene containing a 5.9 kb 5' flanking region of murine cytochrome p450 3a11 (Cyp3a11) promoter, a 200 bp chimeric intron, and modified firefly luciferase cDNA (Promega pGL-3). Basal expression of the reporter in both males and females is high in the intestine. Injection of dexamethasone resulted in a time-dependent induction of luciferase expression, primarily in liver, while seven other tested compounds had minimal effect. This LPTA® animal model is available from Xenogen Biosciences, Cranbury, New Jersey, USA

Model:	Drug Metabolism/Toxicity Model
Mouse Strain:	FVB/N-Tg(Cyp3a11-luc)-Xen
Common Name:	Cyp3a11-luc
Genotype:	Hemizygote
Background Strain:	FVB/N
Coat Color:	Albino