MultiDose® G3 - Automated Dissolution Studies, Testing and Analysis
Overview
The MultiDose G3 is the only fully-automated dissolution studies and dissolution testing system that works within an open architecture, allowing the use of industry standard accessories in a wide variety of configurations. MultiDose G3 performs 8 unattended dissolution runs of different methods and configurations without intervention. The MultiDose G3 automates many testing applications including QA testing and analysis, method development, stablility testing and more.MultiDose G3 Plus provides the added capability of running methods requiring baskets (USP I) and sinkers.
The MultiDose platform has over fourteen years of experience in the pharmaceutical development and quality assurance laboratories. In 2001 the MultiDose platform we converted to be run by Icalis Data Technology Software. The resulting MultiDose G3 now incorporates a modular architecture.
Applications
• USP type I and II Dissolution Testing
• Quality Assurance testing
• Immediate release dosage forms
• Enteric release dosage forms
• Extended release and modified release dosage forms
• Dynamic media preparation
• Method development
• Dosage form development
• Dose Uniformity
• Stability testing analysis
• Quality Assurance testing
• Immediate release dosage forms
• Enteric release dosage forms
• Extended release and modified release dosage forms
• Dynamic media preparation
• Method development
• Dosage form development
• Dose Uniformity
• Stability testing analysis
Features
• A MultiDose G3 used at 50% of its capacity can add the resources equivalent of approximately two analysts
• Frees valuable time for analysts to work on more value-added projects and tasks
• Automated dissolution increases productivity through increased capacity and more consistent, technique independent results
• Advanced media handling capabilities give the G3 the flexibility to address most any method requiring media changes or modifications
• Comprehensive software allows the use of advanced chemometric techniques
• Multiple components can be analyzed within a single dosage form as well as between vessels
• Easy method transfer to other laboratories that have G3
• USP and 21CFR11 compliant operating system provides secure data
• Audit trail helps make the investigation of out of specification results more efficient
• Network capability allows data management and reporting activities to be conducted from an environment external to the lab
The open architecture of MultiDose G3 allows it to support a variety of configuration to fully automate most dissolution testing protocols. The following lists some of the more common configurations:
• MultiDose with MultiFill/Diluter
• MultiDose with MultiFill X2
• MultiDose with Diluter
• MultiDose with Flow-through UV
• MultiDose with Flow-through UV and MultiFill
• MultiDose with Direct MultiChannel HPLC injection
• MultiDose with Sample Collector/Diluter, and HPLC.
• MultiDose with Collector/Diluter and UV or Fluorescence
• MultiDose with Re-circulation Flow-through UV
Supplemental Media for media modification can be added to any configuration (recommended for USP type II methods).
• Frees valuable time for analysts to work on more value-added projects and tasks
• Automated dissolution increases productivity through increased capacity and more consistent, technique independent results
• Advanced media handling capabilities give the G3 the flexibility to address most any method requiring media changes or modifications
• Comprehensive software allows the use of advanced chemometric techniques
• Multiple components can be analyzed within a single dosage form as well as between vessels
• Easy method transfer to other laboratories that have G3
• USP and 21CFR11 compliant operating system provides secure data
• Audit trail helps make the investigation of out of specification results more efficient
• Network capability allows data management and reporting activities to be conducted from an environment external to the lab
The open architecture of MultiDose G3 allows it to support a variety of configuration to fully automate most dissolution testing protocols. The following lists some of the more common configurations:
• MultiDose with MultiFill/Diluter
• MultiDose with MultiFill X2
• MultiDose with Diluter
• MultiDose with Flow-through UV
• MultiDose with Flow-through UV and MultiFill
• MultiDose with Direct MultiChannel HPLC injection
• MultiDose with Sample Collector/Diluter, and HPLC.
• MultiDose with Collector/Diluter and UV or Fluorescence
• MultiDose with Re-circulation Flow-through UV
Supplemental Media for media modification can be added to any configuration (recommended for USP type II methods).
Demos
Our product can be demonstrated at our facility in Hopkinton, Massachussetts or other Caliper Life Sciences offices around the world. Please contact your local Caliper Life Sciences representative to arrange a demo.
Specifications
Capacity |
|
|
|
Increase Capabilities with Optional Accessories |
|
| Support | MultiFill® - Collection and Racks |
| Temp Reading | 4 Port Aux Media Valve and Pump - Allows choice of 4 media |
| Certified Filters | Hot water booster pump provides supplemental pressure to ensure thorough washing. |
| Tube Adapter | 8 Channel diverter valve |
| Evaporation Resistant | Single channel diverter valve for standards |
Supported Third Party Accessories |
|
Baths |
|
| VanKel Varian VK7000 | |
| Hanson SR8 | |
| Distek 2100B, 2100C, 5100 | |
UV Spectrophotometers |
|
| Agilent 8453 | |
| Perkin Elmer Lambda | |
| Shimadzu | |
