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Products and Contract Services

IVIS® SpectrumCT


Next Generation Imaging Technology - IVIS SpectrumCT:


The IVIS SpectrumCT offers the ultimate performance and range of applications for in vivo imaging – leading edge molecular AND anatomical imaging in a single integrated system.  The IVIS SpectrumCT was designed to offer the ultimate range of applications for in vivo and longitudinal imaging.  The system enables synchronization of functional and anatomical data simultaneously and co-registered for true quantitative 3D imaging.

The IVIS SpectrumCT maintains the versatility and the most advanced optical features similar to the world leading imaging platform, the IVIS Spectrum.  Moreover, the IVIS SpectrumCT offers low dose and ultrafast microCT for multiple animals, simultaneously. The average dose per scan is about 10mGy with scanning and reconstruction times of less than a minute.

The SpectrumCT feature sets includes:

  • 3D optical tomography for fluorescence and bioluminescence
  • The industry’s most sensitive detection technology ideal for:
    - Bioluminescence
    - Multispectral fluorescence and spectral unmixing
    - Cerenkov imaging for optical radiotracer imaging
  • Low dose and ultra fast microCT
  • DYCE dynamic enhanced imaging for real time distribution studies of both fluorochromes or PET tracers ideal for PK/PD applications

Quantitative Optical and Computed Tomography
Quantitative Optical and Computed Tomography

Multi-Animal Screening
Multi-Animal Screening
   

DyCE Imaging
DyCE Imaging

High-Throughput
High-Throughput





or contact us at invivoimaging@perkinelmer.com




Applications

•  Oncology Research (PDF)
•  Cerenkov Imaging (Webinar)
•  Inflammation (Webinar)
•  Infectious Diseases (Webinar)
•  Metabolic Diseases and Obesity
•  Neurology (Webinar)
•  Stem cell Biology
•  Cardiovascular Disease
•  Toxicology (PDF)
•  Drug Metabolism Studies

Features

Caliper Life Science’s Spectrum CT is an integrative platform that combines the full suite of IVIS optical features including Spectral Unmixing, 2D and 3D quantitative bioluminescence and fluorescence with fast and low dose CT imaging. The simple user interface along with automated co-registration, advanced visualization and analysis tools are driven by Caliper’s market leading Living Image® software. The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect throughout the complete experimental time frame with both quantitative CT and optical reconstructions. Fast imaging and the ability to image multiple animals offers the throughput required to scan large cohorts of animals quickly and draw sound conclusions from your experimental data.

Demos

Please contact your local Caliper Representative to arrange a live application presentation or demo at one of our Caliper Life Sciences laboratories. SpectrumCT@caliperLS.com

Specifications

Power Requirements
20 Amps for 120 VAC or 10 Amps for 230 VAC

Camera Sensor
Back-thinned, back-illuminated Grade 1 CCD

CCD
Size 2.7 x 2.7 cm
Operating Temperature -90°C

Imaging Pixels
2048 x 2048

Quantum Efficiency
>85% 500 – 700 nm; >30% 400 – 900nm

Pixel Size
13.5 microns

Minimum Detectable Radiance
70 photons/s/sr/cm2

Field of View (FOV)
Maximum FOV 23 x 23cm

Minimum Image Pixel Resolution
20 microns

Read Noise
< 3 electrons for bin=1,2,4; < 5 electrons for bin=8,16

Dark Current (Typical)
<100 electrons/s/cm2

Filter Slots
Fluorescence Excitation 12
Fluorescence Emission 24

Fluorescence Filters
Excitation 10
Emission 18

Heated Chamber
Yes

Diffuse Tomography Software
3D - Yes

Gas Anesthesia
Yes

Computer
Quad Core 2.8 GHz, 12 GB, 1333MHz DDR3, SDRAM, 2GB NVIDIA Quadro 4000 with 256 CUDA Cores, I Tb hard drive, 20” flat screen monitor

Lens
f/1-f/8 = 1.5x, 2.5x, 5x, 8.7x magnifications

Stage Temperature
20 – 40°C

Field of View
30x30x30 to 120x120x30 (L x W x H , mm)

Transillumination Stage
Yes

Workbench
Yes

Imaging System Space Requirement
203 x 163 x 214cm (W x D x H)

Imaging Chamber Interior Dimension
43 x 50 x 60 cm (W x D x H)

Injector ports
Yes

Maximum Energy
Maximum Energy of 50kV with 1mA

Focal spot
50 um

X-ray detector
CMOS

Detector Size
3072 x 864 pixels

Detector ADC Bit Depth
14 bits

Detector operating temp. range
10 - 40 °C

Standard scan time
8 seconds to ~ 2.5 minutes

Standard reconstruction time
minimum of 45s

Standard Scan Dose
minimum of ~10mGy

Safety Requirements
Less than 1 uSeviert/hour max exposure at 5 cm from anywhere outside cabinet, FDA and TUV approved

Software
5 seats (1 aquistion and 4 processing)
Automated co-registration along with tertiary registration.
Advanced visulaizaton and 3D analysis tools for longitudinal uCT applications.
Segmentation, Data processing and transfer enabled for both PC and Mac