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IVIS® Lumina XR


Introducing the IVIS Lumina XR with industry leading Fluorescence, Bioluminescence and now X-Ray.  All-In-One!


IVIS Lumina XR
    •  Uncompromised
    •  Multimodal
    •  Simplified
    •  Flexible




Multimodal Imaging

IVIS Lumina XR offers all the benefits of IVIS Lumina together with x-ray.  Precise optical and X-ray overlay allows you to bring your optical signal into anatomical context. 

Caliper Life Science’s Living Image software automates all the controls and settings required for seamless image acquisition and processing. Typical X-ray image acquisitions take only 10 seconds and can be overlaid with both optical and photographic images. 


Superior Optical Imaging with Spectral Unmixing

The IVIS Lumina XR is capable of imaging all common fluorescent and bioluminescent reporters or dyes. The system is equipped with up to 21 filter sets to image reporters that emit from green to near-infrared. 

High resolution, sharp cut-off filters are simply interchangeable to achieve the highest performance, sensitivity and spectral unmixing. IVIS Lumina XR also accommodates Petri dishes or micro-titer plates for in vitro imaging. The system can incorporate premium animal handling features such as a heated stage, gas anesthesia connections and a syringe injection system for simultaneous compound administration.


Living Image Software

The Living Image software yields high-quality, reproducible, quantitative results incorporating instrument calibration, background subtraction and the image algorithms.  Simple user guided  spectral unmixing allows detection and separation of multiple reporters, and Living Image provides the precise overlay to see your optical reporters together with anatomical surface or X-ray features.




or contact David Panzarella at +1-845-735-1921 or David.Panzarella@caliperls.com




Applications

•  Oncology Research (PDF)
•  Infectious Disease
•  Inflammation
•  Metabolic Disease
•  Neurology
•  Gene Therapy
•  Stem Cell Biology
•  Cardiovascular Disease
•  Immunology & Transplant Biology
•  Toxicology (PDF)
•  Drug Metabolism Studies

Features

Inside the IVIS Lumina XR
      High-sensitivity in vivo and in vitro imaging of fluorescence and bioluminescence
      Back-thinned, back-illuminated grade 1 CCD provides high quantum efficiency over the entire visible to near-infrared spectrum 
      Light-tight imaging chamber
      8 position emission filter wheels
      10 position excitation filter wheels
      5 filter wheel choices for a broad range of fluorescence applications
      LED lamps for photographic images
      Heated stage to maintain optimum body temperature
      Automated motor controlled stage, filter wheel, lens position, and f-stop

X-Ray Module
      Average X-ray acquisition in less than 10 seconds
      Radiation shielded Cabinet
      Exceeds standards set by the US FDA Center for Devices and Radiological Health (21 CFR-1020.40)
      Automated image integration to overlay with Bioluminescence , Fluorescence and Photograph

Optional Accessories
      Optical Zoom Lens attachment for close up and high resolution X-ray  images (available winter 2010)
      Gas anesthesia ports and 3 position manifold within imaging chamber allow anesthesia to be maintained during imaging sessions
      Syringe injection system allows the user to acquire real time functional responses to compounds, by defining amount, flow rate and start time of the pump through Living Image.

 

Specifications

Power Requirements

6A at 120V

Dimensions

System space requirements: 48 x 71 x 104 cm (W x D xH)

Operating System Software

Living Image Software. 1 acquisition copy and 1 analysis copy

Camera Sensor

Back-thinned, back-illuminated, Cooled Grade 1 CCD, frame transfer

CCD

Size 13mm x 13mm
Operating Temperature -90°C

Imaging Pixels

1024 x 1024

Quantum Efficiency

>85% 500 – 700 nm; >30% 400 – 900nm

Pixel Size

13.0 microns

Minimum Detectable Radiance

100 photons/s/sr/cm2

Field of View (FOV)

Minimum FOV 5 x 5 cm
Maximum FOV 12.5 x 12.5 cm

Minimum Image Pixel Resolution

50 microns

Dark Current (Typical)

<3 x10-4e-/pixels/s

Fluorescence Filters

Excitation 10 high resolution filters standard on all instruments
Emission 5 sets available to choose from: One standard resolution set of 4 filters and 4 sets of 7 high resolution filters

Computer

Minimum specifications: 2.8 GHz, 1 GB RAM, RW CD/DVD, 80 GB HD, 20" flat screen monitor

Lens

f/.95 – f/16, 50 mm

Stage Temperature

20 – 40°C

Imaging Chamber Dimensions

48 x 38 x 43 cm (W x D x H)

Radiation shielded Cabinet

Exceeds standards set by the US FDA Center for Devices and Radiological Health (21 CFR-1020.40)

Radiation

< 0.1 mR/hr

Automated aluminum filter

0.4 mm

Plate Voltage Range

4-40kVp

Tube Current Range

1-100uA

Anode Material

Tungsten

Typical X-Ray Image Acquisition Time

10s

Window Filtration

0.127mm beryllium

Scintillator

Automated CsI plate placement during X-Ray acquisition

Imaging System Space Requirement

48 x 71 x 104 cm (W x D x H)

Imaging Chamber Interior Dimension

43 x 38 x 43 cm (W x D x H)

Computer (Minimum specifications)

2.8 GHz, 1 GB RAM, RW CD/DVD, 80 GB HD, 20” flat screen monitor

Living Image Software

1 acquisition copy and 1 analysis copy of Living Image software