KinaseScreen™  PROFILEing

Kinase selectivity profiling is a mainstay of modern drug discovery as target selectivity and specificity are common problems in the identification and development of candidate kinase inhibitors.

A large proportion of kinase inhibitors target the enzyme ATP site making the availability of a wide panel of assays very attractive to determine clear selectivity profiles and possible off-target effects.

KinaseAdvisor™
Profile your lead compounds through the entire kinase panel, or through a customized set of assays, at either a single concentration or in dose response studies (IC₅₀) to evaluate compound selectivity and potency. You can also select a single assay, or a small panel, for profiling large numbers of compounds for lead optimization studies.

     •  Select the assays of interest from the list of protein and lipid kinases below
     •  Duplicate point inhibition data or multiple-doseIC₅₀ curves
     •  All assays run with the ATP concentration at its Km
     •  Reference compound IC₅₀ determined and compared to 
        historical values
     •  Low amount of compound required
     •  Turnaround time: 2 to 3 weeks

        View kinase assay list

RapidKinase™
The RapidKinase profiling service utilizes Caliper’s LabChip^® EZ Reader technology and ProfilerPro reagents to provide kinase profiling data within one week.

RapidKinase 48 is a fixed panel of 48 kinase assays selected due to their therapeutic relevance and diversity across the human kinome.

     •  Duplicate point inhibition data
     •  All assays run with ATP concentration at its Km
     •  Positive and negative controls included in each plate
     •  Low amount of compound required
     •  Turnaround time - 1 week

        View RapidKinase48 assay list



Please contact us via email: CDASinvitro@caliperls.com or use our web-based inquiry form to receive a customized quotation for your RapidKinase Profiling project.