APW3™ - Active Ingredient Processing Workstation
Overview
Caliper has worked with the pharmaceutical industry's most expert automation chemists to design and test this 3rd generation replacement for the Prelude Workstation.
The APW3 accurately automates traditional method steps to disperse, extract, or dissolve active pharmaceutical ingredients or other analytes within 100 X 16 mm test tubes. Dispenses can be set to accurately achieve specified concentration or deliver a specified quantity.
Other capabilities include filtration, dilution, mixing, online LC, and on line UV analysis. An optional sonicating probe facilitates solubility.
Improved Quality of Analysis - The APW3 improves the quality for everyday laboratory tasks by eliminating technique dependency. Accuracy is assured by gravimetric verification of each method step.
Increased Productivity - The labor saved by APW3 allows more time for other, more critical challenges. Many tasks performed by APW3 can do the work of one or more analysts.
Fully Compliant - The APW3 is primarily intended for use within the regulated pharmaceutical industry around the world. Compliance has been taken into consideration for all aspects of use.
Applications
The APW3 is primarily intended to test API’s for stability indicating assay and related compounds. Its flexibility makes it ideally suited for a variety of laboratory applications in analytical development, dose development and quality assurance including:
• Method development and optimization
• API assay and related compounds
• API stability and other impurities
• Forced degradation studies
• Cleaning validation
• Stability Testing
• Stability Studies
• Drug Impurities
• Orthogonal analysis
• Standards preparation
• Low Dose Tablets
• Dose Uniformity
• Creams and semi-solid dosage forms
• Drug loaded medical devices
• Other extractions for assay
• Method development and optimization
• API assay and related compounds
• API stability and other impurities
• Forced degradation studies
• Cleaning validation
• Stability Testing
• Stability Studies
• Drug Impurities
• Orthogonal analysis
• Standards preparation
• Low Dose Tablets
• Dose Uniformity
• Creams and semi-solid dosage forms
• Drug loaded medical devices
• Other extractions for assay
Features
• APW3 gravimetric control reports the exact reagent volume for each dispense. This value is retained in the compliant database to determine dilution factors.
• Since each step is controlled by accurately defined parameters there is no technique dependency. This includes the conditions controlling extractions and dilutions.
• Timing between the method steps, including HPLC injection, is identical for every sample resulting in a uniform sample history.
• Methods may also be overlapped so that the output tube of one method may be the starting point of another method.
• The APW3 includes an interface to Water’s Empower® IITM. The APW3 can also be connected with an on-line generic HPLC and UV spectrophotometer.
• The APW3 is designed to allow multiple dilutions and HPLC injections so that different concentrations from the same extraction can be analyzed.
• Design of experiments, or DOE, is facilitated by the ability to designate analytical parameters as variables. This is a powerful tool that realizes the full potential of automated method development.
• Since each step is controlled by accurately defined parameters there is no technique dependency. This includes the conditions controlling extractions and dilutions.
• Timing between the method steps, including HPLC injection, is identical for every sample resulting in a uniform sample history.
• Methods may also be overlapped so that the output tube of one method may be the starting point of another method.
• The APW3 includes an interface to Water’s Empower® IITM. The APW3 can also be connected with an on-line generic HPLC and UV spectrophotometer.
• The APW3 is designed to allow multiple dilutions and HPLC injections so that different concentrations from the same extraction can be analyzed.
• Design of experiments, or DOE, is facilitated by the ability to designate analytical parameters as variables. This is a powerful tool that realizes the full potential of automated method development.
Demos
Our product can be demonstrated at our facility in Hopkinton, Massachussetts of other Caliper Life Sciences offices around the world. Please contact your local Caliper Representative to arrange a demo.
Specifications
Net Weight |
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| Weight 275 lbs. (124.7 kg) Workstation and Controller | |
Dimensions |
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Capacity |
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Plate Formats |
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| 96- and 384-well |
